منابع مشابه
Annotating N Termini for the Human Proteome Project: N Termini and Nα-Acetylation Status Differentiate Stable Cleaved Protein Species from Degradation Remnants in the Human Erythrocyte Proteome
A goal of the Chromosome-centric Human Proteome Project is to identify all human protein species. With 3844 proteins annotated as "missing", this is challenging. Moreover, proteolytic processing generates new protein species with characteristic neo-N termini that are frequently accompanied by altered half-lives, function, interactions, and location. Enucleated and largely void of internal membr...
متن کاملThe Human Plasma Proteome
The human plasma proteome holds the promise of a revolution in disease diagnosis and therapeutic monitoring provided that major challenges in proteomics and related disciplines can be addressed. Plasma is not only the primary clinical specimen but also represents the largest and deepest version of the human proteome present in any sample: in addition to the classical “plasma proteins,” it conta...
متن کاملAnnotating the human proteome.
The completion of the human genome has shifted the attention from deciphering the sequence to the identification and characterization of the encoded components. The identification and functional annotation of the proteome is here of special interest and starts with the identification of genes and transcripts as a prerequisite of proteome annotation. Gene predictions are very powerful in predict...
متن کاملI-3: Human Y Chromosome Proteome Project 2012 Update
The Human Genome Project has generated a blueprint for the approximately 20,300 gene-encoded proteins potentially active in any of 230 cell types that make up the human body (human proteome). However, based on the UniProtKB/Swiss-Prot database content, about 6000 of at the protein level; for many others, there is very little information related to protein function, abundance, subcellular locali...
متن کاملExploring the human plasma proteome.
The Human Proteome Organization (HUPO) has launched several major initiatives to explore the proteomes of liver, brain, and plasma and to generate informatics standards and large-scale antibody production. This issue of PROTEOMICS presents 28 papers from the pilot phase of the Human Plasma Proteome Project. The papers represent a combination of collaborative analyses of HUPO PPP reference speci...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2004
ISSN: 1535-9476
DOI: 10.1074/mcp.m300132-mcp200